Manchester United could not survive in their Old Trafford Stadium in front of host Fulham, who were tasted by this year's first loss (1-2), on Saturday, as part of the 26th round of the Premier League.
Fulham went ahead with a goal through Calvin Bassey, in the 65th minute, before United equalled the score by Harry Maguire (p 89), but the minute (90 + 7) saw Fulham's lethal goal, through Alex Iwobi.
The defeat kept Man United by 44 points in sixth place, while Fulham raised their tally to 32 in 12th place.
Fulham tried to find their hosts early with a shot from Iwobi, but his ball went by the post, before the Nigerian returned with a fresh try, met the same fate.
Dalot tried his luck with a rocket shot from distance, but the ball set aside the goal, in the Red Devils' first dangerous attempt.
Unana shone in the back of his own goal, with his brilliant save for a powerful right-hander that Pereira fired into the far right corner, turning the United keeper into a corner.
The start of the second half saw Red Devils midfielder Casemiro suffer a head injury, following which coach Eric Ten Hag was forced to replace him.
Reid almost scored for Fulham, sending in a cross from the right, but headed for Onana, who was vigilant and turned the ball into a corner that resulted in a goal for the guests, after the ball fell to Bassey to meet him with a rocket shot into the net.
United defender Harry Maguire rose to Eriksen's cross from a corner, pointing the ball at the top of the crossbar.
A minute before the end of the original time, Fernandes fired a shot from the left, blocked by Leno, but the ball bounced in front of Maguire, who had no difficulty putting it inside the net, to level the score for the Red Devils.
Bruno returned to try his luck with another shot from outside the area, blocked by Leno, but the attack continued and ended with a cross towards Lindelof's head, directing it towards the Fulham goalkeeper, who had no difficulty grabbing it.
Attempts continued against guests with a new correction of Fernandez, to be returned by Leno before being removed from danger zones by defence.
On the other side, Fulham's danger resurfaced, after Muniz met an elaborate cross from the right, with a header that deflected off target.
Fulham stunned their host with a deadly goal from a flash counter attack, which Iwobi finished with an elaborate shot, which Onana had only looked at.
